Cochran was born Oct. 2, 1937 in Shreveport, La., the great-grandson of slaves, grandson of a sharecropper and son of an insurance salesman. He came to Los Angeles with his family in 1949, and in the 1950s, he became one of two dozen black students integrated into Los Angeles High School.
Even as a child, he had loved to argue, and in high school he excelled in debate.
He came to idolize Thurgood Marshall, the attorney who persuaded the
U.S. Supreme Court to outlaw school segregation in the 1954 Brown vs. Board of Education decision and who would eventually become the Supreme Court's first black justice.
"I didn't know too much about what a lawyer did, or how he worked, but I knew that if one man could cause this great stir, then the law must be a wondrous thing," Cochran said in his book. "I read everything I could find about Thurgood Marshall and confirmed that a single dedicated man could use the law to change society."
After graduating from UCLA, Cochran earned a law degree from Loyola University. He spent two years in the Los Angeles city attorney's office before establishing his own practice.
He briefly became a special assistant to the Los Angeles County district attorney in the 1970s, setting up a unit to prosecute domestic violence cases.
After returning to private practice, Cochran built his firm into a personal injury giant with more than 100 lawyers and offices around the country.
Flamboyant in public, he kept his private life shrouded in secrecy, and when some of those secrets became public following a 1978 divorce, they were startling.
His first marriage, to his college sweetheart, Barbara Berry, produced two daughters, Melodie and Tiffany. During their divorce, it came to light that for 10 years Cochran had secretly maintained a "second family," which included a son.
When that relationship soured, his mistress, Patricia Sikora, sued him for palimony and the case was settled privately in 2004.
Although he frequently took police departments on in court, Cochran denied being anti-police and supported the decision of his only son, Jonathan, to join the California Highway Patrol.
He counted among his closest friends Los Angeles City Councilman Bernard Parks, the city's former police chief, and the late Mayor Tom Bradley, who had been a Los Angeles police lieutenant before going into politics.
But in the Simpson case, Cochran turned the murder trial into an indictment of the Police Department, suggesting officers planted evidence in an effort to frame the former football star because he was a black celebrity.
By the time Simpson was acquitted, Cochran and co-counsel Shapiro were on the outs. Shapiro, who is white, had accused Cochran of playing the race card and of dealing it "from the bottom of the deck."
Simpson, meanwhile, was held liable for the killings following a 1997 civil trial and ordered to pay the Brown and Goldman families $33.5 million in restitution. Cochran didn't represent him in that case.
After Simpson, Cochran stepped out of the criminal trial arena, concentrating instead on civil matters. For a time, he represented high-profile athletes and music stars in contract matters. He remained a beloved figure in the black community, admired as a lawyer who was relentless in his pursuit of justice and as a philanthropist who helped fund a UCLA scholarship, a low-income housing complex and a New Jersey legal academy, among other charitable endeavors.